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When does dissatisfation with yourself turn into the complete distruction of your life?

This is my question.

Somehow it seems that when someone isn't satisfied with themselvs it leads to alot of generally bad things. They're sad, quiet, or perhaps rageful. Another thing that seems to happen is suicidal thoughts. I guess the real question is, what happened so bad that the person has come to think that they have no way out?

I once knew a young girl who was very happy, all the time. She was always laughing and smiling. But somewhere along the line it seemed that something got destroyed, and all of her happiness slipped away. I could never really figure out what it was. It seemed like she never wanted to be herself, or live her own life.. only someone elses. I don't think that she ever figured out why things turned out that way. This ultimatley lead to, not the demise of her... but of the little happy girl. It seems she didn't even know how to be herself anymore.

What do you do to help a person like this?